Genomics England
GMS Panels
Panels
Genes and Entities

MSH6

mutS homolog 6
OMIM: 600678
PanelMode of inheritanceDetails
7 panels
Green
in Adult solid tumours cancer susceptibility
Signed-off version 2.2
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Lynch Syndrome, CMMRD
Green
in Haematological malignancies cancer susceptibility
Signed-off version 2.2
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Class: Familial cancer syndrome, Constitutional mismatch repair deficiency syndrome (Lynch syndrome), Lymphoma, ALL, MDS, AML, Brain tumors, gastrointestinal cancers, GI (colon), ovarian, uterine, CNS, other
Green
in Inherited MMR deficiency (Lynch syndrome)
R-numbers: R210
Signed-off version 1.2
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Green
in Inherited ovarian cancer (without breast cancer)
R-numbers: R207
Signed-off version 2.2
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Breast and Ovarian Cancer
Green
in Inherited polyposis
R-numbers: R211, R209
Signed-off version 1.2
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Mismatch repair cancer syndrome 276300 AR, Colorectal cancer, hereditary nonpolyposis, type 5 614350 AD, Endometrial cancer, familial 608089
Green
in Pigmentary skin disorders
R-numbers: R236
Signed-off version 1.4
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
MISMATCH REPAIR CANCER SYNDROME, 276300
Green
in Tumour predisposition - childhood onset
R-numbers: R359
Signed-off version 2.5
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
CMMRD, 276300, Lynch Syndrome