Genomics England
GMS Panels
Panels
Genes and Entities

LAMB1

laminin subunit beta 1
OMIM: 150240
PanelMode of inheritanceDetails
7 panels
Green
in Adult onset leukodystrophy
R-numbers: R62
Signed-off version 3.0
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Phenotypes
Lissencephaly 5, OMIM:615191, cobblestone lissencephaly without muscular or ocular involvement, MONDO:0014077
Green
in Adult onset neurodegenerative disorder
R-numbers: R58
Signed-off version 4.34
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Lissencephaly 5, OMIM:615191, cobblestone lissencephaly without muscular or ocular involvement, MONDO:0014077
Green
in Fetal anomalies
R-numbers: R21, R412
Signed-off version 3.0
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Lissencephaly 5, OMIM:615191, Cobblestone lissencephaly without muscular or ocular involvement, MONDO:0014077
Green
in Hydrocephalus
R-numbers: R86
Signed-off version 4.0
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Lissencephaly 5, OMIM:615191
Green
in Intellectual disability - microarray and sequencing
Component of the following Super Panels:
  • - Childhood onset leukodystrophy
  • - Hypotonic infant
  • - Paediatric disorders
R-numbers: R29
Signed-off version 5.0
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Lissencephaly 5, OMIM:615191
Green
in Malformations of cortical development
Component of the following Super Panels:
  • - Cerebral malformation
Signed-off version 4.0
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Lissencephaly 5 615191
Green
in White matter disorders and cerebral calcification - narrow panel
Component of the following Super Panels:
  • - Childhood onset leukodystrophy
Signed-off version 3.0
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Lissencephaly 5, OMIM:615191, Cystic leukoencephalopathy