Genomics England
GMS Panels
Panels
Genes and Entities

NEXN

nexilin F-actin binding protein
OMIM: 613121
PanelMode of inheritanceDetails
3 panels
Green
in Dilated and arrhythmogenic cardiomyopathy
Component of the following Super Panels:
  • - Sudden unexplained death or survivors of a cardiac event
  • - Unexplained death in infancy and sudden unexplained death in childhood
R-numbers: R132
Signed-off version 4.0
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Cardiomyopathy, dilated, 1CC, OMIM:613122, Cardiomyopathy, dilated, 2M, autosomal recessive, OMIM:621261
Green
in Fetal anomalies
R-numbers: R21, R412
Signed-off version 7.0
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Cardiomyopathy, Cardiomyopathy, dilated, 1CC, OMIM:613122, Cardiomyopathy, hypertrophic, 20, OMIM:613876
Green
in Paediatric or syndromic cardiomyopathy
Component of the following Super Panels:
  • - Unexplained death in infancy and sudden unexplained death in childhood
R-numbers: R135
Signed-off version 8.0
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Phenotypes
Cardiomyopathy, dilated, 1CC, OMIM:613122, Cardiomyopathy, hypertrophic, 20, OMIM:613876