Genomics England

RET

ret proto-oncogene

Panel	Mode of inheritance	Details
Filter panels11 panels
Green in Adult solid tumours cancer susceptibility Signed-off version 2.2	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Multiple Endocrine Neoplasia
Green in Childhood solid tumours R-numbers: R359 Signed-off version 4.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Multiple Endocrine Neoplasia, MEN2B 162300
Green in DDG2P Component of the following Super Panels: - Paediatric disorders Signed-off version 5.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes RENAL AGENESIS 191830, MULTIPLE ENDOCRINE NEOPLASIA IIB 162300
Green in Endocrine neoplasia R-numbers: R217 Signed-off version 3.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes MEN2-like spectrum, Multiple Endocrine Neoplasia Type 2: RET Gene Deletion/Duplication, Multiple endocrine neoplasia IIA, 171400, Endocrine Cancer, Multiple Endocrine Neoplasia
Green in Familial hyperparathyroidism or hypocalciuric hypercalcaemia R-numbers: R151 Signed-off version 3.2	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Multiple endocrine neoplasia IIB (162300), Multiple endocrine neoplasia IIA (171400)/MEN3
Green in Fetal anomalies R-numbers: R21, R412 Signed-off version 5.0	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Phenotypes RENAL AGENESIS, MULTIPLE ENDOCRINE NEOPLASIA IIB
Green in Hirschsprung disease R-numbers: R177 Signed-off version 1.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes
Green in Inherited phaeochromocytoma and paraganglioma excluding NF1 R-numbers: R223 Signed-off version 3.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Multiple endocrine neoplasia IIA, 171400Medullary thyroid carcinoma, 155240Multiple endocrine neoplasia IIB, 162300Central hypoventilation syndrome, congenital, 209880Pheochromocytoma, 171300Renal agenesis, 191830{Hirschsprung disease, susceptibility to, 1}, 142623, Multiple Endocrine Neoplasia
Green in Multiple endocrine neoplasia type 2 R-numbers: R218 Signed-off version 1.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes
Green in Paediatric pseudo-obstruction syndrome R-numbers: R438 Signed-off version 1.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes {Hirschsprung disease, susceptibility to, 1}, 142623, {Hirschsprung disease, protection against}, 142623
Green in Unexplained young onset end-stage renal disease - additional genes Component of the following Super Panels: - Unexplained young onset end-stage renal disease Signed-off version 1.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes {Hirschsprung disease, susceptibility to, 1}, OMIM:142623, Multiple endocrine neoplasia IIA, OMIM:171400, Multiple endocrine neoplasia IIB, OMIM:162300, Pheochromocytoma, OMIM:171300