Genomics England

WRAP53

WD repeat containing antisense to TP53

Panel	Mode of inheritance	Details
Filter panels7 panels
Green in Adult solid tumours cancer susceptibility Signed-off version 2.2	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Dyskeratosis congenita, autosomal recessive 3, 613988
Green in Childhood solid tumours R-numbers: R359 Signed-off version 4.0	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Dyskeratosis congenita, autosomal recessive 3, 613988
Green in Cytopenia - NOT Fanconi anaemia R-numbers: R91 Signed-off version 3.0	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Dyskeratosis congenita, autosomal recessive 3, 613988, 613988 Dyskeratosis congenita, autosomal recessive 3, Dyskeratosis Congenita, Recessive, 300299 Neutropenia, severe congenital, X-linked, Dyskeratosis congenita, Dyskeratosis Congenita, Autosomal Recessive, 3, Inherited Bone Marrow Failure Syndromes
Green in DDG2P Component of the following Super Panels: - Paediatric disorders Signed-off version 3.1	BIALLELIC, autosomal or pseudoautosomal	Phenotypes DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 3 613988
Green in Fetal anomalies R-numbers: R21, R412 Signed-off version 3.0	BIALLELIC, autosomal or pseudoautosomal	Phenotypes DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 3
Green in Haematological malignancies cancer susceptibility Signed-off version 4.0	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Class: BM failure syndrome (typ AR), Dyskeratosis congenita, MDS, AML, Bone marrow failure, macrocytosis, Skin, head and neck, and anogenital squamous cell cancers, Oral and GI squamous cell carcinoma
Green in Pigmentary skin disorders R-numbers: R236 Signed-off version 3.0	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Dyskeratosis congenita, DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 3, DKCB3