Genomics England
GMS Panels
Panels
Genes and Entities

APC

APC, WNT signaling pathway regulator
OMIM: 611731
PanelMode of inheritanceDetails
5 panels
Green
in Adult solid tumours cancer susceptibility
Signed-off version 2.2
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Familial Adenomatous Polyposis
Green
in APC associated Polyposis
R-numbers: R414
Signed-off version 1.4
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Desmoid disease, hereditary, OMIM:135290, Adenomatous polyposis coli, OMIM:175100, Brain tumor-polyposis syndrome 2, OMIM:175100, Gardner syndrome, OMIM:175100, Gastric adenocarcinoma and proximal polyposis of the stomach, OMIM:619182, desmoid tumor, MONDO:0007608, gastric adenocarcinoma and proximal polyposis of the stomach, MONDO:0017790, familial adenomatous polyposis 1, MONDO:0021056
Green
in Brain cancer pertinent cancer susceptibility
Signed-off version 1.0
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Adult Glioma
Green
in Childhood solid tumours
Signed-off version 5.11
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Familial Adenomatous Polyposis, 175100
Green
in Inherited polyposis and early onset colorectal cancer - germline testing
R-numbers: R211
Signed-off version 4.2
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Desmoid disease, hereditary, OMIM:135290, Brain tumor-polyposis syndrome 2, OMIM:175100, Gardner syndrome, OMIM:175100, Adenomatous polyposis coli, OMIM:175100, Gastric adenocarcinoma and proximal polyposis of the stomach, OMIM:619182