Genomics England

SDHB

succinate dehydrogenase complex iron sulfur subunit B

Panel	Mode of inheritance	Details
Filter panels9 panels
Green in Adult solid tumours cancer susceptibility Signed-off version 2.2	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Familial Paraganglioma and Pheochromocytoma
Green in Inherited phaeochromocytoma and paraganglioma excluding NF1 R-numbers: R223 Signed-off version 4.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Paragangliomas 4, OMIM:115310, Pheochromocytoma, OMIM:171300, Paraganglioma and gastric stromal sarcoma, OMIM:606864
Green in Inherited predisposition to GIST R-numbers: R363 Signed-off version 1.15	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Gastrointestinal stromal tumor, OMIM:606764, Paraganglioma and gastric stromal sarcoma, OMIM:606864, Carney-Stratakis syndrome, MONDO:0011740
Green in Inherited renal cancer R-numbers: R224 Signed-off version 1.28	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Paragangliomas 4, OMIM:115310, Pheochromocytoma, OMIM:171300, Paraganglioma and gastric stromal sarcoma, OMIM:606864
Green in Likely inborn error of metabolism Component of the following Super Panels: - Childhood onset leukodystrophy - Hypotonic infant - Paediatric disorders - Unexplained death in infancy and sudden unexplained death in childhood R-numbers: R98 Signed-off version 9.0	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
Green in Mitochondrial disorder with complex II deficiency R-numbers: R354 Signed-off version 2.2	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
Green in Mitochondrial disorders Component of the following Super Panels: - Childhood onset leukodystrophy Signed-off version 10.0	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
Green in Possible mitochondrial disorder - nuclear genes R-numbers: R63 Signed-off version 5.0	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
Green in White matter disorders and cerebral calcification - narrow panel Component of the following Super Panels: - Childhood onset leukodystrophy - Paediatric disorders Signed-off version 8.0	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224