Genomics England

TP53

tumor protein p53

OMIM: 191170

Panel	Mode of inheritance	Details
Filter panels10 panels
Green in Adult solid tumours cancer susceptibility Signed-off version 2.2	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Li Fraumeni Syndrome
Green in Brain cancer pertinent cancer susceptibility Signed-off version 1.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Adult Glioma
Green in Breast cancer pertinent cancer susceptibility Signed-off version 2.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Breast cancer
Green in Childhood solid tumours Signed-off version 5.11	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Adrenocortical carcinoma, Li Fraumeni Syndrome
Green in Embryonal tumour of possible germline origin R-numbers: R456 Signed-off version 1.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes {Colorectal cancer}, OMIM:114500, {Adrenocortical carcinoma, pediatric}, OMIM:202300, choroid plexus papilloma, MONDO:0009837, {Choroid plexus papilloma}, OMIM:260500, Li-Fraumeni syndrome, MONDO:0018875, nasopharyngeal carcinoma, susceptibility to, 1, MONDO:0011775, {Basal cell carcinoma 7}, OMIM:614740, Li-Fraumeni syndrome, OMIM:151623, basal cell carcinoma, susceptibility to, 7, MONDO:0013876, {Glioma susceptibility 1}, OMIM:137800, adrenocortical carcinoma, hereditary, MONDO:0008734
Green in Haematological malignancies cancer susceptibility Signed-off version 5.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Class: Familial cancer syndrome, Li-Fraumeni syndrome, ALL, AML, MDS, Adrenal, breast, brain, and lung sarcoma, gastrointestinal cancers, Breast cancer, osteosarcoma, soft tissue sarcomas, brain tumors, adrenocortical carcinoma
Green in Inherited predisposition to acute myeloid leukaemia (AML) R-numbers: R347 Signed-off version 3.5	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Li-Fraumeni syndrome, OMIM:151623, Li-Fraumeni syndrome 1, MONDO:0007903
Green in Li Fraumeni Syndrome R-numbers: R216 Signed-off version 1.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes
Green in Sarcoma of possible germline origin R-numbers: R457 Signed-off version 1.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes {Colorectal cancer}, OMIM:114500, basal cell carcinoma, susceptibility to, 7, MONDO:0013876, adrenocortical carcinoma, hereditary, MONDO:0008734, {Glioma susceptibility 1}, OMIM:137800, nasopharyngeal carcinoma, susceptibility to, 1, MONDO:0011775, Li-Fraumeni syndrome, OMIM:151623, Li-Fraumeni syndrome, MONDO:0018875, {Basal cell carcinoma 7}, OMIM:614740, choroid plexus papilloma, MONDO:0009837, {Adrenocortical carcinoma, pediatric}, OMIM:202300, {Choroid plexus papilloma}, OMIM:260500
Green in Sarcoma susceptibility Signed-off version 1.2	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Sarcoma, Li-Fraumeni syndrome, 151623