Genomics England
GMS Panels
Panels
Genes and Entities

TP53

tumor protein p53
OMIM: 191170
PanelMode of inheritanceDetails
8 panels
Green
in Adult solid tumours cancer susceptibility
Signed-off version 2.2
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Li Fraumeni Syndrome
Green
in Brain cancer pertinent cancer susceptibility
Signed-off version 1.0
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Adult Glioma
Green
in Breast cancer pertinent cancer susceptibility
Signed-off version 2.0
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Breast cancer
Green
in Childhood solid tumours
R-numbers: R359
Signed-off version 4.0
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Adrenocortical carcinoma, Li Fraumeni Syndrome
Green
in Haematological malignancies cancer susceptibility
Signed-off version 4.0
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Class: Familial cancer syndrome, Li-Fraumeni syndrome, ALL, AML, MDS, Adrenal, breast, brain, and lung sarcoma, gastrointestinal cancers, Breast cancer, osteosarcoma, soft tissue sarcomas, brain tumors, adrenocortical carcinoma
Green
in Inherited predisposition to acute myeloid leukaemia (AML)
R-numbers: R347
Signed-off version 3.0
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Li-Fraumeni syndrome, OMIM:151623, Li-Fraumeni syndrome 1, MONDO:0007903
Green
in Li Fraumeni Syndrome
R-numbers: R216
Signed-off version 1.0
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Green
in Sarcoma susceptibility
Signed-off version 1.2
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Sarcoma, Li-Fraumeni syndrome, 151623