Genomics England

Genes and Entities

Sarcoma of possible germline origin (Version: )

Relevant disorders: R457

Signed off date: 6 May 2026

Panel types: GMS Rare Disease Virtual, GMS Rare Disease, GMS signed-off

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13 green entities

Entity rating	Entity	Mode of inheritance	Mode of pathogenicity	Tags
Green	BUB1B	BIALLELIC, autosomal or pseudoautosomal	N/A	N/A
Green	CBL	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	DICER1	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	N/A	N/A
Green	HRAS	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	KRAS	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	NBN	BIALLELIC, autosomal or pseudoautosomal	N/A	N/A
Green	NF1	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	PTPN11	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	RB1	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	RECQL4	BIALLELIC, autosomal or pseudoautosomal	N/A	N/A
Green	T	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	new-gene-name, gene-duplication
Green	TP53	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	WRN	BIALLELIC, autosomal or pseudoautosomal	N/A	N/A