Genomics England

Genes and Entities

Multiple monogenic benign skin tumours (Version: )

Relevant disorders: R230, GT811, TP538

Signed off date: 12 Aug 2026

Panel types: GMS Rare Disease Virtual, GMS Rare Disease, GMS signed-off

See this panel in PanelApp

6 green entities

Entity rating	Entity	Mode of inheritance	Mode of pathogenicity	Tags
Green	CYLD	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	N/A	N/A
Green	FLCN	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	N/A	N/A
Green	LEMD3	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	N/A	N/A
Green	MLH1	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	N/A	N/A
Green	MSH2	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	N/A	N/A
Green	PDGFRB	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	N/A	N/A