Genomics England

Genes and Entities

Familial tumours of the nervous system (Version: )

Relevant disorders: R221

Signed off date: 6 May 2026

Panel types: GMS Rare Disease Virtual, GMS Rare Disease, GMS signed-off

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7 green entities

Entity rating	Entity	Mode of inheritance	Mode of pathogenicity	Tags
Green	CDKN2A	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	N/A	N/A
Green	DGCR8	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	gene-checked
Green	LZTR1	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	NF2	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	SMARCB1	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	SMARCE1	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A
Green	SUFU	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	N/A	N/A